Least sedating antihistamine

"The first-generation antihistamines are more sedating, but the distinction isn't as black-and-white as the marketing of the newer products may lead you to believe.

The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD.

In severe allergies, such as anaphylaxis or angioedema, these effects may be of life-threatening severity.

Additional administration of epinephrine, often in the form of an autoinjector, is required by people with such hypersensitivities.-antihistamines can be administered topically (through the skin, nose, or eyes) or systemically, based on the nature of the allergic condition.

So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.

Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications.

The reason for their peripheral selectivity is that most of these compounds are zwitterionic at physiological p H (around p H 7.4).

These agents also commonly have action at α-adrenergic receptors and/or 5-HT receptors.

The second-generation H receptors and cholinergic receptors.

This selectivity significantly reduces the occurrence of adverse drug reactions, such as sedation, while still providing effective relief of allergic conditions.

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